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butabarbital will lower the level or impact of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Outcome of coadministering a robust CYP3A4 inducer with fedratinib has not been studied.butabarbital will lower the extent or impact of carvedilol by influencing hepatic enzyme CYP2C9/ten metaboli